研究成果

Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model.
Murata, K., Makino, A., Tomonaga, K., and Masumoto, H.
iScience. 27(1), : 108641. (2024)

Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota).
Kuhn, J.H., Abe, J., Adkins, S., Alkhovsky, S.V., Avšič-Županc, T., Ayllón, M.A., Bahl, J., Balkema-Buschmann, A., Tomonaga, K., et al.
J Gen Virol. 104(8), 001864. (2023)

Reverse genetics of parrot bornavirus 4 reveals a unique splicing of the glycoprotein gene that affects viral propagation.
Komorizono, R., Fujino, K., Kessler, S., Runge, S., Kanda, T., Horie, M., Makino, A., Rubbenstroth, D., and Tomonaga, K.
J Virol. 97(8), e0050923. (2023)

Quick and affordable DNA cloning by reconstitution of Seamless Ligation Cloning Extract using defined factors.
Liu, A.Y., Koga, H., Goya, C., and Kitabatake, M.
Genes Cells. 28(8), :553-562. (2023)

The hidden diversity of ancient bornaviral sequences from X and P genes in vertebrate genomes.
Garcia, B.C.B., Mukai, Y., Tomonaga, K., and Horie, M.
Virus Evol. 8, vead038. (2023)

Contact-number-driven virus evolution: a multi-level modeling framework for the evolution of acute or persistent RNA virus infection.
Sunagawa J, Komorizono R, Park H, Hart WS, Thompson RN, Makino A, Tomonaga K, Iwami S, Yamaguchi R.
PLOS Comput Biol. (in press)

Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model.
Minamiyama S, Sakai M, Yamaguchi Y, Kusui M, Wada W, Hikiami R, Yoshitaka T, Asada M, Shodai A, Makino A, Fujiwara N, Ayaki T, Maki T, Warita H, Aoki M, Tomonaga K, Takahashi R, Urushitani M.
Mol Ther Methods Clin Dev. (in press)

Ribavirin treatment of severe schizophrenia with positive anti-Borna disease virus antibodies 30 years after onset: a case report.
Matsunaga H, Fukumori A, Mori K, Morihara T, Sato S, Kitauchi K, Yanagida K, Taguchi K, Honda T, Tomonaga K.
Case Rep Psychiatry. (in press)

Borna disease virus 1 phosphoprotein forms a tetramer and in-teracts with host factors involved in DNA double-strand break repair and mRNA processing.
Tarbouriech N, Chenavier F, Kawasaki J, Bachiri K, Bourhis JM, Legrand P, Freslon L, Roy A, Laurent EMN, Suberbielle E, Ruigrok RWH, Tomonaga K, Gonzalez-Dunia D, Horie M, Coyaud E, Crpin T.
Viruses 14(11):2358 (2022)

A Multicenter study to investigate the positive rate of SARS-CoV-2 in middle ear and mastoid specimens from otologic surgery patients.
Yamazaki H, Yamamoto N, Sonoyama T, Nasu S, Maruoka H, Makino A, Tomonaga K, N Shigemoto, Ohge H, Fujiwara K, Shinohara S, Takeno S, Omori K, Naito Y.
Auris Nasus Larynx S0385-8146(22)00193-6. (2022)

Exogenous expression of both matrix protein and glycoprotein facilitates the infectious viral particle production of Borna disease virus 1.
Kanda T, Sakai M, Makino A, Tomonaga K.
J Gen Virol. 103(7):001767. (2022)

A comprehensive profiling of innate immune responses in Eptesicus bat cells.
Lin HH, Horie M, Tomonaga K.
Microbiol Immunol. 66(3):97-112. (2022)

Waning of anti-SARS-CoV-2 spike antibody levels 100 to 200 days after the second dose of the BNT162b2 vaccine.
Matsunaga H, Takeuchi H, Oba Y, Fujimi S, Honda T, Tomonaga K.
Vaccines 10(2):177. (2022)

An endogenous bornavirus-like nucleoprotein in miniopterid bats retains the RNA-binding properties of the original viral protein.
Mukai Y, Horie M, Kojima S, Kawasaki J, Maeda K, Tomonaga K.
FEBS lett. 596(3):323-337. (2022)

Stability of Borna disease virus-based episomal vector under physical and chemical stimulation.
Yanai M, Sakai M, Komorizono R, Makino A, Tomonaga K.
Microbiol Immunol. 66(1):24-30. (2022)

Borna disease virus phosphoprotein triggers the organization of viral inclusion bodies by liquid-liquid phase separation.
Hirai Y, Tomonaga K, Horie M.
Int J Biol Macromol. 192:55-63. (2021)

The Borna disease virus (BoDV) 2 nucleoprotein is a conspecific protein that enhances BoDV-1 RNA-dependent RNA polymerase activity.
Kanda T, Horie M, Komatsu Y, Tomonaga K.
J Virol. 95(21):e0093621. (2021)

BUD23-TRMT112 interacts with the L protein of Borna disease virus and mediates the chromosomal tethering of viral ribonucleoproteins.
Garcia BCB, Horie M, Kojima S, Makino A, Tomonaga K.
Microbiol Immunol. 65(11):492-504. (2021)

Hidden viral infections in public sequencing data and warning for future emerging diseases.
Kawasaki J, Kojima S, Tomonaga K, Horie M.
mBio 2(4):e0163821. (2021)

A human endogenous bornavirus-like nucleoprotein encodes a mitochondrial protein associated with cell viability.
Fujino K, Horie M, Kojima S, Shimizu S, Nabekura A, Kobayashi H, Makino A, Honda T, Tomonaga K.
J Virol. 95(14):e02030-20. (2021)

One hundred million years history of bornavirus infections hidden in vertebrate genomes.
Kawasaki J, Kojima S, Mukai Y, Tomonaga K, Horie M.
Proc Natl Acad Sci USA. 118(20):e2026235118. (2021)

Characterization of an active LINE-1 in the naked mole-rat genome.
Yamaguchi S, Nohara S, Nishikawa Y, Tomonaga K, Ueda K, Honda T.
Sci Rep. 11(1):5725. (2021)

Radioligand assay-based detection of antibodies against SARS-CoV-2 in hospital workers treating patients with severe COVID-19 in Japan.
Matsunaga H, Makino A, Kato Y, Murakami T, Yamaguchi Y, Kumanogoh A, Oba Y, Fujimi S, Honda T, Tomonaga K.
Viruses 13(2):347. (2021)

Identifications of novel avian and mammalian deltaviruses provides new insights into deltavirus evolution.
Iwamoto M, Shibata Y, Kawasaki J, Kojima S, Li YT, Iwami S, Muramatsu M, Wu HL, Wada K, Tomonaga K, Watashi K, Horie M.
Virus Evol. 7(1):veab003. (2021)

Virus-like insertions with sequence signatures similar to those of endogenous non-retroviral RNA viruses in the human genome.
Kojima S, Yoshikawa K, Ito J, Nakagawa S, Parrish NF, Horie M, Kawano S, Tomonaga K.
Proc Natl Acad Sci USA. 118(5):e2010758118. (2021)

Optimal expression of the envelope glycoprotein of orthobornaviruses determines the production of mature virus particles.
Sakai M, Fujita Y, Komorizono R, Kanda T, Komatsu Y, Noda T, Tomonaga K, Makino A.
J Virol. 95:e02221-20. (2021)

Identification of a reptile lyssavirus in Anolis allogus provided novel insights into lyssavirus evolution.
Horie M, Akashi H, Kawata M, Tomonaga K.
Virus Genes. 57(1):40-49. (2021)

Evolutionary selection of nuclear localization signal of viral nucleoprotein leads to host adaptation of the genus Orthobornavirus.
Komorizono R, Sassa Y, Horie M, Makino A, Tomonaga K.
Viruses 12(11):1291. (2020)

Modeling Borna disease virus spread reveals the mode of antiviral effect conferred by an endogenous bornavirus-like element.
Kim KS, Yamamoto Y, Nakaoka S, Tomonaga K, Iwami S, Honda T.
J Virol. 94(21):e01204-20. (2020)

Production of high-titer transmission-defective RNA virus-based episomal vector using tangential flow filtration.
Komatsu Y, Kakuya Y, Tomonaga K.
Microbiol Immunol. 64(9):602-609. (2020)

In vivo biodistribution analysis of transmission competent and defective RNA virus-based episomal vector.
Komatsu Y, Tanaka C, Komorizono R, Tomonaga K.
Sci Rep. 10(1):5890. (2020)

Differential roles of two DDX17 isoforms in the formation of membraneless organelles.
Hirai Y, Domae E, Yoshikawa Y, Tomonaga K.
J Biochem. 168(1):33-40 (2020)

ADAR2 is involved in self and nonself recognition of Borna disease virus genomic RNA in the nucleus.
Yanai M, Kojima S, Sakai S, Komorizono R, Tomonaga K, Makino A.
J Virol. 94(6):e01513-19 (2020)

Development of a reverse transcription-loop-mediated isothermal amplification assay for the detection of parrot bornavirus 4.
Komorizono R, Tomonaga K, Makino A.
J Virol Methods. 275:113749 (2020)

Development of an RNA virus-based episomal vector capable of switching transgene expression.
Yamamoto Y, Tomonaga K, Honda T.
Front Microbiol. 10:2485. (2019)

Identification of a distinct lineage of aviadenovirus from crane feces.
Mukai Y, Tomita Y, Kryukov K, Nakagawa S, Ozawa M, Matsui T, Tomonaga K, Imanishi T, Kawaoka Y, Watanabe T, Horie M.
Virus Genes. (2019)

RNA virus-based episomal vector with a fail-safe switch facilitating efficient genetic modification and induced differentiation of iPSCs.
Komatsu Y, Takeuchi D, Tokunaga T, Sakurai H, Makino A, Honda T, Ikeda Y and Tomonaga K.
Mol Ther Methods Clin Dev. 14:47-55. (2019)

Intracellular dynamics of actin affects Borna disease virus replication in the nucleus.
Hirai Y, Domae E, Yoshikawa Y, Okamura H, Makino A and Tomonaga K.
Virus Res 263:179-183 (2019)

Splicing-dependent subcellular targeting of Borna disease virus nucleoprotein isoforms.
Kojima S, Sato R, Yanai M, Komatsu Y, Horie M, Igarashi M and Tomonaga K.
J Virol 93(5) e01621-1618 (2019)

Systematic estimation of insertion dates for endogenous bornavirus-like elements in vesper bats.
Mukai Y, Horie and Tomonaga K.
J Vet. Med. Sci 80:1356-1363 (2018)

Two neuropsychiatric cases seropositive for bornavirus improved by ribavirin.
Matsunaga H, Fukumori A, Mori K, Honda T, Uema T, Tomonaga K.
Jpn J Infect Dis 71:338-342 (2018)

Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder.
Honda T, Sofuku K, Matsunaga H, Tachibana M, Mohri I, Taniike M, Tomonaga K.
Microbiol Immunol 62:473-476 (2018)

Degradation of amyloid β peptide by neprilysin expressed from Borna disease virus vector.
Sakai M, Ueda S, Daito T, Asada-Utsugi M, Komatsu Y, Kinoshita A, Maki T, Kuzuya A, Takahashi R, Makino A and Tomonaga K.
Microbiol Immunol 62:467-472 (2018)

Regnase-1 and Roquin non-redundantly regulate Th1 differentiation causing cardiac inflammation and fibrosis.
Cui XT, Mino T, Yoshinaga M, Nakatsuka Y, Hia F, Yamasoba D, Tsujimura T, Tomonaga K, Suzuki Y, Uehata T and Takeuchi O.
J. Immunol. 199:4066-4077 (2017)

Generation of a non-transmissive Borna disease virus vector lacking both matrix and glycoprotein.
Fujino K, Yamamoto Y, Daito T, Makino A, Honda T and Tomonaga K.
Microbiol Immunol. 61:380-386 (2017)

Linkage between the leader sequence and leader RNA production in Borna disease virus-infected cells.
Honda T, Sofuku K, Kojima S, Yamamoto Y, Ohtaki N and Tomonaga K.
Virology 510:104-110 (2017)

Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein.
Yanai M, Sakai M, Makino A and Tomonaga K.
Virol J. 14:126 (2017)

Antiviral activity of Favipiravir (T-705) against mammalian and avian bornaviruses.
Tokunaga T, Yamamoto Y, Sakai M, Tomonaga K and Honda T.
Antiviral Res. 143:237-245 (2017)

Detection of antibodies against Borna disease virus proteins in an autistic child and her mother.
Honda T, Sofuku K, Matsunaga H, Tachibana M, Mohri I, Taniike M, and Tomonaga K.
Jpn J Infect Dis. 70:225-227 (2017)

Possibility and challenges of conversion of current virus species names to Linnaean binomials.
Postler TS, Clawson AN, Amarasinghe GK, Basler CF, Bavari S, Benkő M, Blasdell KR, Briese T, Buchmeier MJ, Bukreyev A, Calisher CH, Chandran K, Charrel R, Clegg CS, Collins PL, de la Torre JC, DeRisi JL, Dietzgen RG, Dolnik O, Dürrwald R, Dye JM, Easton AJ, Emonet S, Formenty P, Fouchier RA, Ghedin E, Gonzalez JP, Harrach B, Hewson R, Horie M, Jiāng D, Kobinger G, Kondo H, Kropinski AM, Krupovic M, Kurath G, Lamb RA, Leroy EM, Lukashevich IS, Maisner A, Mushegian AR, Netesov SV, Nowotny N, Patterson JL, Payne SL, Paweska JT, Peters CJ, Radoshitzky SR, Rima BK, Romanowski V, Rubbenstroth D, Sabanadzovic S, Sanfaon H, Salvato MS, Schwemmle M, Smither SJ, Stenglein MD, Stone DM, Takada A, Tesh RB, Tomonaga K, Tordo N, Towner JS, Vasilakis N, Volchkov VE, Wahl-Jensen V, Walker PJ, Wang LF, Varsani A, Whitfield AE, Zerbini FM, Kuhn JH.
Syst Biol 66:463-473 (2017)

Borna disease virus assembles porous cage-like viral factories in the nucleus.
Hirai Y, Hirano Y, Matsuda A, Hiraoka Y, Honda T and Tomonaga K.
J Biol Chem 291:25789-25798 (2016)

Sequence determination of a new parrot bornavirus-5 strain in Japan; implication of clade specific sequence diversity in the regions interacting with host factors.
Komorizono R, Makino A, Horie M, Honda T and Tomonaga K.
Microbiol Immunol 60:437-441 (2016)

Long-term expression of miRNA for RNA interference using a novel vector system based on a negative-strand RNA virus.
Honda T, Yamamoto Y, Daito T, Matsumoto Y, Makino A and Tomonaga K.
Sci Rep 6:26154 (2016)

An RNA-dependent RNA polymerase gene in bat genomes derived from an ancient RNA virus.
Horie M, Kobayashi Y, Honda T, Fujino K, Akasaka T, Kohl C, Wibbelt G, Mühldorfer K, Kurth A, Müller MA, Corman VM, Gillich N, Suzuki Y, Schwemmle M and Tomonaga K.
Sci Rep 6:25873 (2016)

Isolation of avian bornaviruses from psittacine birds using QT6 quail cells in Japan.
Horie M, Sassa Y, Iki H, Ebisawa K, Fukushi H, Yanai T and Tomonaga K.
J. Vet. Med. Sci. 78:305-308 (2016)

A novel intranuclear RNA vector system for long-term stem cell modification.
Ikeda Y, Makino A, Holditch SJ, Lu B, Dietz AB and Tomonaga K.
Gene Ther 23:256-262 (2016)

Influenza A virus-induced expression of a GalNAc transferase, GALNT3, via miRNAs is required for enhanced viral replication.
Nakamura S, Horie M, Daidoji T, Honda T, Yasugi M, Kuno A, Komori T, Okuzaki D, Narimatsu H, Nakaya T and Tomonaga K.
J. Virol. 90:1788-1801 (2015)

X-linked RNA-binding motif protein (RBMX) is required for the maintenance of Borna disease virus nuclear viral factories.
Hirai Y, Honda T, Makino A, Watanabe Y and Tomonaga K.
J. Gen. Virol. 96:3198-3203 (2015)

Parrot bornavirus-2 and -4 RNA detected in wild bird samples in Japan are phylogenetically adjacent to those found in pet birds in Japan.
Sassa Y, Bui VN, Saitoh K, Watanabe Y, Koyama S, Endoh D, Horie M, Tomonaga K, Furuya T, Nagai M, Omatsu T, Imai K, Ogawa H, Mizutani T.
Virus Genes 51:234-243 (2015)

Transcription profiling demonstrates epigenetic control of non-retroviral RNA virus-derived elements in the human genome.
Sofuku K, Parrish NF, Honda T and Tomonaga K.
Cell Rep. 12:1548-1554 (2015)

piRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals.
Parrish NF, Fujino K, Shiromoto Y, Iwasaki YW, Ha H, Xing J, Makino A, Kuramochi-Miyagawa S, Nakano T, Siomi H, Honda T and Tomonaga K.
RNA 21:1691-1703 (2015)

IFN-β-inducible, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA type-dependent manner.
Yoshida A, Kawabata R, Honda T, Tomonaga K, Sakaguchi T and Irie T.
Front. Microbiol. 6:804 (2015)

Borna disease virus possesses an NF-κB inhibitory sequence in the nucleoprotein gene.
Makino A, Fujino K, Honda T, Parrish NF and Tomonaga K.
Sci. Rep. 5:8696 (2015)

Taxonomic reorganization of the family Bornaviridae.
Kuhn JH, Dürrwald R, Bo Y, Briese T, Carbone K, Clawson AN, deRisi JL, Garten W, Jahrling PB, Kolodziejek J, Rubbenstroth D, Schwemmle M, Stenglein M, Tomonaga K, Weissenbck H and Nowotny N.
Arch Virol. 160:621-632 (2015)

Heat stress is a potent stimulus for enhancing rescue efficiency of recombinant Borna disease virus.
Kojima S, Honda T, Matsumoto Y and Tomonaga K.
Microbiol. Immunol. 58:636-642 (2014).

Origin of endogenous bornavirus-like nucleoprotein elements in thirteen-lined ground squirrels.
Suzuki Y, Kobayashi Y, Horie M and Tomonaga K.
Genes Genet. Syst. 89:143-148 (2014).

Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome.
Fujino K, Horie M, Honda T, Merriman DK and Tomonaga K.
Proc. Natl. Acad. Sci. USA. 111:13175-13180 (2014).

Comprehensive analysis of bornavirus-like elements in eukaryote genomes.
Horie M, Kobayashi Y, Suzuki Y and Tomonaga K.
Philos. Trans. R. Soc. Lond.-B Biol. Sci. 368:20120499. (2013)

Molecular epidemiology of avian bornavirus from pet birds in Japan.
Sassa Y, Horie M, Fujino K, Nishiura N, Okazaki S, Furuya T, Nagai M, Omatsu T, Kojima A, Mizugami M, Ueda K, Iki H, Ebisawa K, Tomonaga K and Mizutani T.
Virus Genes 47:173–177 (2013)

Evolutionarily conserved interaction between the phosphoproteins and X proteins of bornaviruses from different vertebrate species.
Fujino K, Horie M, Honda T, Nakamura S, Matsumoto Y, Francischetti I. M. B and Tomonaga K.
PLoS One 7:e51161 (2012).

Generation of human bronchial epithelial cell lines expressing inactive mutants of GALNT3.
Nakamura S, Horie M, Fujino K, Matsumoto Y, Honda T and Tomonaga K.
J. Vet. Med. Sci. 74:1493-1496 (2012)

Bornavirus closely associates and segregates with host chromosomes to ensure persistent intranuclear infection.
Matsumoto Y, Hayashi Y, Omori H, Honda T, Daito T, Horie M, Ikuta K, Fujino K, Nakamura S, Schneider U, Chase J, Yoshimori T, Schwemmle M and Tomonaga K.
Cell Host Microbe 11:492-503 (2012)

Detection of avian bornavirus 5 RNA in Eclectus roratus with feather picking disorder.
Horie M, Ueda K, Ueda A, Honda T and Tomonaga K.
Microbiol. Immunol. 56:346-349 (2012)

A novel Borna disease virus vector system that stably expresses foreign proteins from an intercistronic noncoding region.
Daito T, Fujino K, Honda T, Matsumoto Y, Watanabe Y and Tomonaga K.
J. Virol. 85: 12170-12178 (2011)

No evidence for natural selection on endogenous Borna-like nucleoprotein elements after the divergence of Old World and New World monkeys.
Kobayashi Y, Horie M, Tomonaga K and Suzuki Y.
PLoS One 6:e24403 (2011)

Analysis of intracellular distribution of Borna disease virus glycoprotein fused with fluorescent markers in living cells.
Daito T, Fujino K, Watanabe Y, Ikuta K and Tomonaga K.
J. Vet. Med. Sci. 73: 1243-1247 (2011)

Upregulation of insulin-like growth factor binding protein 3 in astrocytes of transgenic mice that express Borna disease virus phosphoprotein.
Honda T, Fujino K, Okuzaki D, Ohtaki N, Matsumoto Y, Horie M, Daito T, Itoh M and Tomonaga K.
J. Virol. 85: 4567-4571 (2011)

ボルナ病と診断された猫における臨床徴候に関する一考.
町田 晴市, 川村 知世, 宇根 有美, 朝長 啓造, 長谷川 大輔, 織間 博光.
獣医神経病　11:3-9 (2010)

Endogenous non-retroviral RNA virus elements in mammalian genomes.
Horie M, Honda T, Suzuki Y, Kobayashi Y, Daito T, Oshida T, Ikuta K, Jern P, Gojobori T, Coffin JM and Tomonaga K.
Nature 463:84-87 (2010)

Molecular chaperone BiP interacts with Borna disease virus glycoprotein at cell surface.
Honda T, Horie M, Daito T, Ikuta K and Tomonaga K.
J. Virol. 83:12622-12625 (2009)

Autogenous translational regulation of the Borna disease virus negative control factor X from polycistronic mRNA using host RNA helicases.
Watanabe Y, Ohtaki N, Hayashi Y, Ikuta K and Tomonaga K.
PLoS Pathog. 5:e1000654 (2009)

Heat shock cognate protein 70 controls Borna disease virus replication via interaction with the viral non-structural protein X.
Hayashi Y, Horie M, Daito T, Honda T, Ikuta K and Tomonaga K.
Microbes Infect. 11:3940-3402 (2009)

Ribavirin inhibits Borna disease virus proliferation and fatal neurological diseases in neonatally infected gerbils.
Lee B-J, Matsunaga H, Ikuta K and Tomonaga K.
Antiviral Res. 80:380-384 (2008)

Isotype analysis of human anti-Borna disease virus antibodies in Japanese psychiatric and general population.
Matsunaga H, Tanaka S, Fukumori A, Tomonaga K, Ikuta K, Amino N, Takeda M.
J. Clin. Virol. 43:317-322 (2008)

Downregulation of an astrocyte-derived inflammatory protein, S100B, reduces vascular inflammatory responses in brains persistently infected with Borna disease virus.
Ohtaki N, Kamitani W, Watanabe Y, Hayashi Y, Yanai H, Ikuta K and Tomonaga K.
J. Virol. 81:5940-5948 (2007)

Characterization of a Borna disease virus field isolate which shows efficient viral propagation and transmissibility.
Watanabe Y, Ibrahim MS, Hagiwara K, Okamoto M, Kamitani W, Yanai H, Ohtaki N, Hayashi Y, Taniyama H, Ikuta K and Tomonaga K.
Microbes Infect. 9:417-427 (2007)

Borna disease virus matrix protein is an integral component of the viral ribonucleoprotein complex that does not interfere with polymerase activity.
Chase G, Mayer D, Hildebrand A, Frank R, Hayashi Y, Tomonaga K and Schwemmle M.
J. Virol. 81:743-749 (2007)

脳内にクリプトコッカスとボルナ病ウイルスが重複感染した猫の1例. 動物臨床医学
田村 慎司, 田村 由美子, 鈴岡 宣孝, 大岡 恵, 長谷川 孝寿, 内田 和幸, 渡邊 洋平, 朝長 啓造.
J. Anim. Clin. Med. 15:49-52. (2006)

Development of a novel Borna disease virus reverse genetics system using RNA polymerase II promoter and SV40 nuclear import signal.
Yanai H, Hayashi Y, Watanabe Y, Ohtaki N, Kobayashi T, Nozaki Y, Ikuta K and Tomonaga K.
Microbes Infect. 8:1522-1529 (2006)

Prevalence of Borna disease virus antibodies in healthy Japanese black cattle in Kyushu.
Watanabe Y, Yanai H, Ohtaki N, Ikuta K and Tomonaga K.
J. Vet. Med. Sci. 68:171-174 (2006)

A methionine-rich domain mediates CRM1-dependent nuclear export activity of Borna disease virus phosphoprotein.
Yanai H, Kobayashi T, Hayashi Y, Watanabe Y, Ohtaki N, Zhang G, de la Torre JC, Ikuta K and Tomonaga K.
J. Virol. 80:1121-1129 (2006)

頻発する首振り発作にリバビリンが奏効した統合失調症の1例－ボルナ病ウイルスとの関連の可能性－.
松永 秀典, 上間 武, 原元 燈, 田口 智己, 朝長 啓造, 生田 和良, 武田 雅俊.
精神科治療学 20:1057-1065. (2005)

猫のボルナ病：1例報告.
鶴岡 浩志, 渡邊 洋平, 朝長 啓造.
動物臨床医学 J. Anim. Clin. Med. 14:105-108. (2005)

Enzootic intranasal tumour virus infection in apparently healthy sheep in Japan.
Kawasako K, Okamoto M, Kurosawa T, Nakade T, Kirisawa R, Miyashou T, Komine M, Go T, Imazu S, Takeuchi N, Tomonaga K, Ikuta K, Akihara Y, Shimoyama Y, Hirayama K and Taniyama H.
Vet. Rec. 157:118 (2005)

Detection of antibodies against Borna disease virus by a radioligand assay in patients with various psychiatric disorders.
Matsunaga H, Tanaka S, Sasao F, Nishino Y, Takeda M, Tomonaga K, Ikuta K and Amino N.
Clin. Diagn. Lab. Immunol. 12:671-676 (2005)

Prevention of PERV infections in pig to human xenotransplantation by the RNA interference silences gene.
Miyagawa S, Nakatsu S, Nakagawa T, Kondo A, Matsunami K, Hazama K, Yamada J, Tomonaga K, Miyazawa T and Shirakura R.
J. Biochem. (Tokyo) 137:503-508. (2005)

The effect of expression of complement regulatory protein on pig endothelial cells to pig endogenous retrovirus lyses by human sera.
Hazama K, Miyagawa S, Yamamoto A, Kubo T, Miyazawa T, Tomonaga K, Watanabe R, Okumura M, Matsuda H and Shirakura R.
Transplant. Proc. 37:503-505. (2005)

Persistent Borna disease virus infection confers instability of HSP70 mRNA in glial cells during heat stress.
Yamashita M, Kamitani W, Yanai H, Ohtaki N, Watanabe Y, Lee B-J, Tsuji S, Ikuta K and Tomonaga K*.
J. Virol. 79:2033-2041 (2005)

Age- and host-dependent control of Borna disease virus spread in the developing brains of gerbils and rats.
Lee B-J, Watanabe M, Yamashita M, Kamitani W, Kobayashi T, Tomonaga K* and Ikuta K.
Microbes Infect. 5:1195-1204 (2003)

Experimental transmission of abnormal prion protein (PrPSc) in the small intestinal epithelial cells of neonatal mice.
Okamoto M, Furuoka H, Horiuchi M, Noguchi T, Hagiwara K, Muramatsu Y, Tomonaga K, Tsuji S, Ishihara C, Ikuta K and Taniyama H.
Vet. Pathol. 40:723-727. (2003)

The significance of N-linked glycosylation in pig endogenous retrovirus infectivity.
Hazama K, Miyagawa S, Miyazawa T, Yamada J, Tomonaga K, Ota M, Matsuda H and Shirakura R.
Biochem. Biophys. Res. Commun. 310:327-333. (2003)

Sensitivity of human serum of the gammaretroviruses produced from pig endothelial cells transduced with glycosyltransferase genes.
Kurihara T, Miyazawa T, Miyagawa S, Tomonaga K, Hazama K, Yamada J, Shirakura R and Matsuura Y.
Xenotransplantation 10:562-568. (2003)

Borna disease virus phosphoprotein represses p53-mediated transcriptional activity by interference with HMGB1.
Zhang G, Kobayashi T, Kamitani W, Komoto S, Yamashita M, Baba S, Yanai H, Ikuta K and Tomonaga K*.
J. Virol. 77:12243-12251. (2003)

Experimental vertical transmission of Borna disease virus in the mouse.
Okamoto M, Hagiwara K, Kamitani W, Sako T, Hirayama K, Kirisawa R, Tsuji M, Ishihara C, Iwai H, Kobayashi T, Tomonaga K, Ikuta K and Taniyama H.
Arch. Virol. 148:1557-1568. (2003)

Glial expression of Borna disease virus phosphoprotein induces behavioral and neurological abnormalities in transgenic mice.
Kamitani W, Ono E, Yoshino S, Kobayashi T, Taharaguchi S, Lee B-J, Yamashita M, Kobayashi T, Okamoto M, Taniyama H, Tomonaga K* and Ikuta K.
Proc. Natl. Acad. Sci. USA. 100:8969-8974 (2003)

Modulation of Borna disease virus phosphoprotein nuclear localization by the viral protein X encoded in the overlapping open reading frame.
Kobayashi T, Zhang G, Lee B-J, Baba S, Yamashita M, Kamitani W, Yanai H, Tomonaga K* and Ikuta K.
J. Virol.77:8099-8107. (2003)

Borna disease virus induces acute fatal neurological disorders in neonatal gerbils without virus- and immune-mediated cell destructions.
Watanabe M, Lee B-J, Yamashita M, Kamitani W, Kobayashi T, Tomonaga K* and Ikuta K.
Virology 310:245-253. (2003)

Varied persistent life cycles of Borna disease virus in a human oligodendroglioma cell line.
Ibrahim MS, Watanabe M, Palacios JA, Kamitani W, Komoto S, Kobayashi T, Tomonaga K and Ikuta K.
J. Virol. 76:3873-3880. (2002)

抗ボルナ病ウイルス抗体を認めた4例の臨床的検討.
松永 秀典, 西野 佳似, 林 宏恵, 小林 剛, 朝長 啓造, 笹尾 芙蓉子, 生田 和良.
脳と精神の医学 12:139-147. (2001)

Borna disease virus phosphoprotein binds a neurite outgrowth factor, amphoterin/HMG-1.
Kamitani W, Shoya Y, Kobayashi T, Watanabe M, Lee B-J, Zhang G, Tomonaga K* and Ikuta K.
J. Virol. 75:8742-8751. (2001)

Neurological diseases and viral dynamics in the brains of neonatally Borna disease virus-infected gerbils.
Watanabe M, Lee B-J, Kamitani W, Kobayashi T, Taniyama H, Tomonaga K* and Ikuta K.
Virology 282:65-76. (2001)

Borna disease virus nucleoprotein requires both nuclear localization and export activities for viral nucleocytoplasmic shuttling.
Kobayashi T, Watanabe M, Kamitani W, Zhang G, Tomonaga K* and Ikuta K.
J. Virol. 75:3404-3412. (2001)